Paroxetine vs Escitalopram (2026)

Quick answer: Paroxetine 7.5mg (Brisdelle) is the only FDA-approved nonhormonal prescription for hot flashes; trials showed a modest but significant reduction versus placebo. Escitalopram is off-label with comparable trial efficacy and is often better tolerated.

Sources(2)

Peer-reviewed and regulatory references. External links open in new tab.

FDA label: Brisdelle (paroxetine 7.5 mg) — moderate-to-severe VMS ↗
Freeman EW et al. Efficacy of escitalopram for hot flashes in healthy menopausal women (RCT). JAMA, 2011 ↗

Compare Paroxetine vs Escitalopram

Both medications in the MENTAL-HEALTH category. Deep clinical comparison coming soon. See all medications for now.