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Editorial reviews. Affiliate fees from some providers don't affect rankings. Disclosure

No advertiser influenceAffiliate fees disclosedReviewed by board-certified clinicians

Women's hormonal health A-Z

Complete library of 30+ conditions, symptoms, and life phases. Each entry has plain-English explanation, when to see a doctor, and treatment options.

Side effect comparison across hormonal treatments

Frequencies derived from drug labels + clinical literature. Individual response varies.

Side effectHRT (oral)HRT (transdermal)GLP-1SSRISpironolactoneSERM (raloxifene)
NauseaCommonUncommonCommonCommonRareRare
Breast tendernessCommonCommonNot reportedRareCommonUncommon
Mood changesUncommonUncommonRareCommonRareRare
Weight gainUncommonRareNot reportedCommonRareRare
Weight lossNot reportedNot reportedCommonRareNot reportedNot reported
Blood clot riskUncommonRareNot reportedRareNot reportedUncommon
HyperkalemiaNot reportedNot reportedNot reportedNot reportedCommonNot reported
GI distress (diarrhea/constipation)UncommonRareCommonCommonUncommonRare
Hair lossRareRareUncommonRareNot reportedRare
Libido changesCommonCommonNot reportedCommonUncommonNot reported
CommonUncommonRareNot reported

Always discuss side effect risk profile with your prescribing clinician.