GLP-1 — Frequently asked questions
GLP-1 receptor agonists (semaglutide, tirzepatide) treat chronic obesity and T2D. Common questions: safety, side effects, compounded vs branded, insurance coverage, duration of therapy.
6 questions answered by our NAMS-certified editorial team.
Can I take GLP-1 medications with HRT?
YesYes, GLP-1 medications (semaglutide, tirzepatide) and hormone therapy can generally be taken together with no known interactions. Many perimenopausal and postmenopausal women take both safely.
Is compounded semaglutide safe?
It dependsCompounded semaglutide from licensed 503A pharmacies is legal in the US during ongoing FDA-listed semaglutide shortage. Safety depends on the pharmacy's 503A status, ingredient sourcing, and medical oversight.
Is compounded progesterone safe?
It dependsCompounded progesterone is safe when prescribed by a licensed clinician through 503A pharmacy. Most evidence supports FDA-approved oral micronized progesterone (Prometrium) over custom-compounded.
When should I stop taking GLP-1?
Discuss with your clinician after reaching weight goal or if serious side effects appear. Most patients regain 50-60% of lost weight within 12 months of stopping — chronic therapy commonly recommended.
Is it safe to drink alcohol on GLP-1?
It dependsModerate drinking generally safe but expect amplified effects + increased nausea risk. GLP-1 slows gastric emptying — alcohol absorption changes. Many patients report reduced alcohol cravings.
Is microdosing GLP-1 effective?
It dependsMicrodosing (e.g., 0.1-0.25 mg semaglutide) has limited clinical trial evidence. Some patients report appetite reduction at sub-therapeutic doses. Effects on weight loss likely minimal.
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