GLP-1 — Frequently asked questions

• Can I take GLP-1 medications with HRT?

  Yes

  Yes, GLP-1 medications (semaglutide, tirzepatide) and hormone therapy can generally be taken together with no known interactions. Many perimenopausal and postmenopausal women take both safely.

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• Is compounded semaglutide safe?

  It depends

  Compounded semaglutide from licensed 503A pharmacies is legal in the US during ongoing FDA-listed semaglutide shortage. Safety depends on the pharmacy's 503A status, ingredient sourcing, and medical oversight.

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• Is compounded progesterone safe?

  It depends

  Compounded progesterone is safe when prescribed by a licensed clinician through 503A pharmacy. Most evidence supports FDA-approved oral micronized progesterone (Prometrium) over custom-compounded.

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• When should I stop taking GLP-1?

  Discuss with your clinician after reaching weight goal or if serious side effects appear. Most patients regain 50-60% of lost weight within 12 months of stopping — chronic therapy commonly recommended.

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• Is it safe to drink alcohol on GLP-1?

  It depends

  Moderate drinking generally safe but expect amplified effects + increased nausea risk. GLP-1 slows gastric emptying — alcohol absorption changes. Many patients report reduced alcohol cravings.

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• Is microdosing GLP-1 effective?

  It depends

  Microdosing (e.g., 0.1-0.25 mg semaglutide) has limited clinical trial evidence. Some patients report appetite reduction at sub-therapeutic doses. Effects on weight loss likely minimal.

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Other FAQ topics

• HRT

  Frequently asked questions about hormone replacement therapy for menopause + perimenopause.

• PCOS

  Frequently asked questions about polycystic ovary syndrome — diagnosis, treatment, fertility, lifestyle.

• Perimenopause

  Frequently asked questions about perimenopause — early signs, lab work, symptom management.