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Q&A

hrt · compounded-hormones

Is compounded progesterone safe?

Written byEditorial Team, HormonalHealth PortalReviewed byEditorial Medical Review, MD, NAMS-CMP· Updated May 15, 2026
Maybe — depends on context

Compounded progesterone is safe when prescribed by a licensed clinician through 503A pharmacy. Most evidence supports FDA-approved oral micronized progesterone (Prometrium) over custom-compounded.

The detail

Compounded progesterone may use inconsistent doses across batches. ACOG generally prefers FDA-approved oral micronized progesterone. Compounded vaginal/topical progesterone widely used clinically but lacks robust efficacy data vs oral. Cost difference often minimal — choose FDA-approved when available.

Sources

SC
Reviewed by Editorial Medical ReviewBoard-certified OB/GYN · NAMS-certified · Updated 2026-05-15

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