Medication guide · Updated 2026
Weak estrogen frequently included in compounded "BiEst" preparations. Not FDA-approved as standalone in US.
Generic name
Compounded Estriol
Drug class
hormone-hrt
Brand names
—
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0 brands
Educational reference only. Not medical advice. Verify dose, indications, and interactions with a licensed prescriber.
Compounded Estriol is a hormone therapy used to replace or modulate endogenous hormone levels (commonly estrogen, progesterone, or testosterone). Only compounded formulations are currently in widespread use — no FDA-approved branded version exists or it has been withdrawn.
Compounded Estriol is typically prescribed for patients managing perimenopause, menopause, or post-menopausal hormonal changes — typically those with vasomotor symptoms (hot flashes, night sweats), sleep disruption, or bone density concerns. As with all prescription medications, suitability is determined by a licensed clinician based on individual medical history, current medications, and treatment goals.
Average monthly cost runs around $65, though actual pricing depends heavily on strength, pharmacy, and insurance coverage.
Before starting Compounded Estriol, ask your prescribing clinician about: your full medication and supplement list (for interaction screening), recent labs that are relevant to the medication's mechanism, monitoring cadence after starting, and what specific outcome they expect to see in the first 4–12 weeks.
Weak estrogen frequently included in compounded "BiEst" preparations. Not FDA-approved as standalone in US.
Compounded Estriol is administered hormone-hrt. Doses depend on indication and patient response. See the brand pages above for program-specific dosing.
Coverage varies wildly by plan tier and indication. Many GLP-1 + HRT medications require prior authorization. Some compounded versions are not insurance-billable. See individual brand pages for coverage status.
Side effects vary. Review the prescribing information and report symptoms to your provider.
Drug-drug interactions matter — especially for HRT + thyroid + GLP-1 combinations. Use our drug interaction checker, and always disclose your full medication list to the prescriber.
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