Switching guide
How to switch from compounded progesterone to Prometrium
Standard switch to FDA-approved oral micronized progesterone. Improves dose precision and insurance coverage.
Reviewed by ClearHormones Editorial Team · Updated 2026-04-20
Why switch
- Want FDA-approved formulation
- Insurance covers Prometrium
- Endometrial protection requires verified dose
Why not to switch
- Allergy to peanut oil (Prometrium contains)
- Sleepy side effect from oral progesterone
Step-by-step
- Confirm dose equivalenceTypical: 100 mg compounded ≈ 100 mg Prometrium oral. Cyclic dosing 12-14 days/month, or continuous 100 mg daily.
- Start Prometrium during next progesterone cycleTake at bedtime for drowsiness benefit. Begin same day compounded would have started.
- Monitor sleep + moodMost patients sleep better. Some report morning grogginess — try 30 min earlier if needed.
- 6-week follow-upDiscuss symptoms, side effects, and continuation plan with prescriber.
- Confirm dose equivalence(Week 0)Typical: 100 mg compounded ≈ 100 mg Prometrium oral. Cyclic dosing 12-14 days/month, or continuous 100 mg daily.
- Start Prometrium during next progesterone cycle(Week 1)Take at bedtime for drowsiness benefit. Begin same day compounded would have started.
- Monitor sleep + mood(Weeks 1-4)Most patients sleep better. Some report morning grogginess — try 30 min earlier if needed.
- 6-week follow-up(Week 6)Discuss symptoms, side effects, and continuation plan with prescriber.
⚠ Warnings
- Take at bedtime — sedating effect
- Peanut oil allergy contraindication
- Pregnancy category B
Other switching guides
Not medical advice. Always discuss medication changes with your prescriber. See our editorial methodology.