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Q&A

pcos · spironolactone

Can I take spironolactone long-term for PCOS?

Written byEditorial Team, HormonalHealth PortalReviewed byEditorial Medical Review, MD, NAMS-CMP· Updated May 15, 2026
Yes — generally safe

Yes, spironolactone is commonly used long-term (years) for PCOS-related hirsutism, acne, and hair loss. Monitor potassium and blood pressure annually.

The detail

Spironolactone (100-200 mg/day typical) blocks androgen receptors. Long-term safety profile good. Annual monitoring: potassium (hyperkalemia rare unless renal impairment), BP. Pregnancy contraindicated — feminizing effects on male fetus. Must pair with reliable contraception.

Sources

SC
Reviewed by Editorial Medical ReviewBoard-certified OB/GYN · NAMS-certified · Updated 2026-05-15

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