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Can I take GLP-1 with HRT?
Yes. GLP-1 medications and hormone therapy work through separate pathways and have no known interactions. Many perimenopausal women take both safely.
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Is compounded semaglutide safe?
It depends. Legal via licensed 503A pharmacies during the FDA shortage — but the FDA does not review compounded products. Verify the pharmacy status and sourcing.
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Why does perimenopause cause anxiety?
Fluctuating estrogen disrupts serotonin and norepinephrine — both involved in mood regulation. The anxiety is biological, not just stress.
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How long do hot flashes last?
Median total duration is 7.4 years per the SWAN study — longer than previously thought. About 1 in 3 women experience them for 10+ years.
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When should I start HRT?
NAMS recommends starting HRT under age 60 or within 10 years of menopause onset for the best safety profile. Earlier in that window is often better for symptom control.
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How long does HRT take to work?
Hot flashes ease in 2-4 weeks. Sleep and mood follow in 4-8 weeks. Vaginal symptoms improve in 8-12 weeks. Full benefit is assessed at 3 months.
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Why does perimenopause cause weight gain?
Three drivers: estrogen shifts fat from hips to abdomen, ~1%/year muscle loss from sarcopenia, and a 30-50% drop in insulin sensitivity.
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Why does PCOS cause hair loss?
Elevated androgens (testosterone, DHEAS) bind to scalp follicles, causing androgenetic alopecia. The same mechanism drives body hirsutism.
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When should I stop taking GLP-1?
Discuss with your clinician after reaching goal or if serious side effects appear. Most patients regain 50-60% of lost weight within 12 months of stopping.
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Why does menopause cause joint pain?
Estrogen has anti-inflammatory effects. Its decline triggers low-grade systemic inflammation — showing up as joint stiffness in fingers, hands, and knees.
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