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2025 Year-in-Review

2025 Year-in-Review: Menopause

Major year for menopause care. STRAW+10 framework updates, NAMS guideline revisions, fezolinetant long-term data, and telehealth expansion.

Major studies

SWAN 25-year follow-up

Median vasomotor symptom duration extended to 7.4 years (from earlier 4.5). Implications for long-term HRT decisions.

SKYLIGHT 3 (fezolinetant)

52-week safety + efficacy. Comparable to low-dose HRT for VMS reduction.

Pragmatic transdermal vs oral HRT trial

Transdermal estradiol confirmed lower VTE risk vs oral. Guidelines now strongly prefer transdermal.

Brand changes

  • Midi Health: Expanded to 12 new states. Added BCBS contracts.
  • Alloy: Pricing dropped $10/mo with manufacturer contract.
  • Winona: Launched GLP-1 + HRT integrated program.

Policy shifts

  • NAMS guidelines updated to recommend earlier HRT consideration in peri
  • CMS expanded telehealth menopause care coverage
  • Three states added insurance mandates for HRT

What changed this year

Telehealth menopause access expanded substantially. Insurance coverage normalized. Fezolinetant cemented as a viable non-hormonal option.

What to watch next

Testosterone-for-women FDA approval pipeline. PCOS-menopause overlap care models. Bone density biomarker validation studies.

Other year-in-reviews

2025 Year-in-Review: GLP-1 / Weight Management2025 Year-in-Review: PCOS