Loss of normal ovarian function before age 40, causing irregular periods and low estrogen.
Also known as: primary ovarian insufficiency, premature ovarian insufficiency, premature ovarian failure
Primary ovarian insufficiency (POI) is when the ovaries stop working normally before age 40. It can cause irregular or absent periods and menopause-like symptoms.
POI is not the same as early menopause; some ovarian activity can come and go. Because of the health effects of prolonged low estrogen, it is evaluated and managed by a clinician.