Estradiol transdermal patch dosing schedules below follow FDA prescribing information. Your prescriber sets your specific dose — these are reference ranges, not personal medical advice.
Available forms(1)
Transdermal patch (matrix), replaced once or twice weekly
Vasomotor symptoms (hot flashes, night sweats)
Typical delivery 0.025-0.1 mg/day
Climara and Menostar are weekly patches; Vivelle-Dot, Minivelle, and Alora are twice-weekly
Start at the lowest effective dose and titrate to symptom control
Osteoporosis prevention (postmenopausal)
Low-dose patches such as Menostar deliver 0.014 mg/day
Add a progestogen periodically if the uterus is intact
Missed dose
If a patch falls off or a change is missed, apply a new patch as soon as you notice and return to your original weekly/twice-weekly schedule — do not double up.