Estradiol transdermal patch and Pregnancy

Last reviewed: 7/3/2026 · How we review →

Estradiol is contraindicated in pregnancy. Menopausal hormone therapy is used after the reproductive years and offers no benefit in pregnancy.

Pregnancy safety

Estradiol transdermal patch pregnancy safety summary
FDA category	X (contraindicated)
Breastfeeding	Estrogens can reduce the quantity and quality of breast milk and are generally avoided during lactation; discuss with your clinician.