Estradiol vaginal cream dosing schedules below follow FDA prescribing information. Your prescriber sets your specific dose — these are reference ranges, not personal medical advice.
Available forms(1)
Vaginal cream with calibrated applicator (0.01%, 0.1 mg estradiol per gram)
Genitourinary syndrome of menopause (vulvar/vaginal atrophy)
Estrace label: an initial 2-4 g/day for 1-2 weeks, then gradual reduction
Maintenance around 1 g one to three times weekly
Clinicians often use the lowest dose that controls symptoms
Missed dose
Apply the missed dose when you remember, unless it is nearly time for the next application — then skip it. Do not double up.